The role of COMT, DAT and DRD2 polymorphisms on brain mechanisms of involuntary attention and cognitive control
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چکیده
منابع مشابه
Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia
BACKGROUND Cognitive deficits such as poor selective attention and executive functions decline have been reported in patients with schizophrenia. Many studies have emphasized the role of dopamine in regulating cognitive functions in the general population as well as in schizophrenia. However, the relationship between cognitive processes, schizophrenia and dopaminergic candidate genes is an orig...
متن کاملAn association study between genetic variants at mu-opioid receptor, dopamine transporter, catechol- O-methyltransferase, and dopamine genes and risk of Parkinson’s disease
Background: Parkinson’s disease (PD) is a complex disorder that involves multiple genetic and environmental factors. Several candidate genes have been speculated to be involved in the development of PD. We conducted a case-control study to investigate the association between PD and single nucleotide polymorphisms (SNP) at the OPRM1, DAT, COMT and DRD2 genes in a Taiwanese population. Methods: T...
متن کاملThe Association of DRD2 Gene TaqI Polymorphism with Attention Deficit Hyperactivity Disorder a Population Sample of Iranian Azeri-children
Background Attention deficit hyperactivity disorder (ADHD) is a multi-factorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotide polymorphisms in DRD2 gene, Taq I A (T/C) and Taq I B (G/A), with ADH...
متن کاملCommonly-occurring polymorphisms in the COMT, DRD1 and DRD2 genes influence different aspects of motor sequence learning in humans
Performing sequences of movements is a ubiquitous skill that involves dopamine transmission. However, it is unclear which components of the dopamine system contribute to which aspects of motor sequence learning. Here we used a genetic approach to investigate the relationship between different components of the dopamine system and specific aspects of sequence learning in humans. In particular, w...
متن کاملCOMT and ANKK1-Taq-Ia Genetic Polymorphisms Influence Visual Working Memory
Complex cognitive tasks such as visual working memory (WM) involve networks of interacting brain regions. Several neurotransmitters, including an appropriate dopamine concentration, are important for WM performance. A number of gene polymorphisms are associated with individual differences in cognitive task performance. COMT, for example, encodes catechol-o-methyl transferase the enzyme primaril...
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تاریخ انتشار 2009